Subacute toxicity study of the methanolic seed extract of Buchholzia coriacea (Capparaceae) in rats
The methanol extract of Buchholzia coriacea seed has shown some anti-trypanosomal activity against Trypanosoma brucei brucei . The acute toxicity test of this extract showed no signs of toxicity. This present study was designed to assess its sub-acute toxicity in rats. Rats of both sexes were dosed...
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| Veröffentlicht in: | Comparative clinical pathology 2012-10, Vol.21 (5), p.967-974 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The methanol extract of
Buchholzia coriacea
seed has shown some anti-trypanosomal activity against
Trypanosoma brucei brucei
. The acute toxicity test of this extract showed no signs of toxicity. This present study was designed to assess its sub-acute toxicity in rats. Rats of both sexes were dosed daily with 125, 250 and 500 mg/kg body weight of the extract by oral gavage for 28 days. Dosing with the extract showed no significant effect on body weights. The temperatures of extract-treated rats were significantly (
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| ISSN: | 1618-5641 1618-565X |
| DOI: | 10.1007/s00580-011-1210-y |