Synthesis of 1-(1H-Tetrazol-5-yl)-2H-isoindole Derivatives through Ugi Four-Component and Silver-Catalyzed Reactions

A facile and efficient one‐pot, two‐step synthesis of 1,2‐disubstituted 3‐(1H‐tetrazol‐5‐yl)‐2H‐isoindoles through Ugi four‐component reaction/AgNO3‐catalyzed reaction of 2‐alkynylbenzaldehydes, amines, isonitriles, and Me3SiN3 is described. This transformation proceeds through 5‐exo‐dig cyclization...

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Veröffentlicht in:	European journal of organic chemistry 2014-06, Vol.2014 (16), p.3379-3386
Hauptverfasser:	Wu, Ran, Gao, Shang, Chen, Xu, Yang, Guanghui, Pan, Lingling, Hu, Gaobo, Jia, Ping, Zhong, Weihui, Yu, Chuanming
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Cyclization Multicomponent reactions Nitrogen heterocycles Silver
Online-Zugang:	Volltext
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