Synthesis of 1-(1H-Tetrazol-5-yl)-2H-isoindole Derivatives through Ugi Four-Component and Silver-Catalyzed Reactions

A facile and efficient one‐pot, two‐step synthesis of 1,2‐disubstituted 3‐(1H‐tetrazol‐5‐yl)‐2H‐isoindoles through Ugi four‐component reaction/AgNO3‐catalyzed reaction of 2‐alkynylbenzaldehydes, amines, isonitriles, and Me3SiN3 is described. This transformation proceeds through 5‐exo‐dig cyclization, [1,3]‐H shift, and [1,5]‐H shift to generate the products in moderate to excellent yields. A one‐pot, two‐step synthesis of 1‐(1H‐tetrazol‐5‐yl)‐2H‐isoindole derivatives through Ugi four‐component reaction/AgNO3‐catalyzed reaction of 2‐alkynylbenzaldehydes, amines, isonitriles, and Me3SiN3 has been developed. The transformation proceeds through 5‐exo‐dig cyclization, [1,3]‐H shift, and [1,5]‐H shift to generate the products in moderate to excellent yields.