Solvent-Free Buchwald-Hartwig Reaction of Aryl and Heteroaryl Halides with Secondary Amines

A highly efficient solvent‐free protocol for the Buchwald–Hartwig amination of (hetero)aryl halides by secondary amines was developed. The reaction is mediated by a Pd(OAc)2/RuPhos catalytic system in air. Various (hetero)aryl halides were coupled with diaryl, alkyl–aryl, and dialkylamines in good t...

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Veröffentlicht in:	European journal of organic chemistry 2014-06, Vol.2014 (16), p.3319-3322
Hauptverfasser:	Topchiy, Maxim A., Asachenko, Andrey F., Nechaev, Mikhail S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amination Cross-coupling Palladium Solvent-free reactions
Online-Zugang:	Volltext
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