Solvent-Free Buchwald-Hartwig Reaction of Aryl and Heteroaryl Halides with Secondary Amines

A highly efficient solvent‐free protocol for the Buchwald–Hartwig amination of (hetero)aryl halides by secondary amines was developed. The reaction is mediated by a Pd(OAc)2/RuPhos catalytic system in air. Various (hetero)aryl halides were coupled with diaryl, alkyl–aryl, and dialkylamines in good to excellent yields (51 examples, 50–99 % yield). Disubstituted amines are efficiently coupled with aryl and heteroaryl halides through Buchwald–Hartwig amination under solvent‐free aerobic conditions. The reaction is catalyzed by a Pd(OAc)2/RuPhos system in air. Various (hetero)aryl halides are coupled with diaryl, alkyl–aryl, and dialkylamines in good to excellent yields.