N-nitrosodiethylamine induced redox imbalance in rat liver: Protective role of polyphenolic extract of Blighia sapida arilli

This study investigates the reactive oxygen species detoxification potentials of polyphenolic extract of Blighia sapida arilli in the liver of N-nitrosodiethylamine-treated rats. Male rats, weighing 158 ± 2.9 g were completely randomized into 7 groups (A–G) of five rats each. Rats in C, D, E and F were administered orally once daily at 24 h interval for 7 days with 1000, 250, 500 and 1000 mg/kg body weight of polyphenolic extract of B. sapida arilli respectively. Group G was given 100 mg/kg body weight of vitamin C. On the sixth day, group B, D, E, F and G were administered with 100 mg/kg body weight N-nitrosodiethylamine (NDEA). Group A, which served as the control was treated like the test groups except, that the animals received distilled water only. Reactive oxygen species detoxifying enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase) activities were significantly (P