Acquired hypothyroidism in an infant related to excessive maternal iodine intake: food for thought

Adverse effects of excess iodine on thyroid function in the fetus and breast-fed infant have recently become more common due to the ingestion of iodine-rich dietary supplements during and after pregnancy and consumption of seaweed soup by Korean mothers to enhance lactation. A breast-fed 4-week-old...

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Veröffentlicht in:Endocrine practice 2013-07, Vol.19 (4), p.729-731
Hauptverfasser: Shumer, Daniel E, Mehringer, Jamie E, Braverman, Lewis E, Dauber, Andrew
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Sprache:eng
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Zusammenfassung:Adverse effects of excess iodine on thyroid function in the fetus and breast-fed infant have recently become more common due to the ingestion of iodine-rich dietary supplements during and after pregnancy and consumption of seaweed soup by Korean mothers to enhance lactation. A breast-fed 4-week-old female infant was recently referred to Boston Children's Hospital because of a 3-day history of progressive jaundice and decreased oral intake. Due to concern of the possibility of iodine toxicity, analysis of the mother's breast milk expressed on the day of presentation revealed a markedly elevated iodine concentration of 3,023 mg/L (normal median values, 45.6 mg/L and 155 mg/L in separate studies of Boston-area women (2,3)). The infant's spot urine iodine was also markedly elevated to 1,830 mg/L (normal median, 197 mg/L in Boston (3)) 1 day following presentation. In this case, maternal iodine intoxication is implicated as the cause of overt hypothyroidism in a breast-fed infant.
ISSN:1530-891X
1934-2403
DOI:10.4158/EP13017.CO