Phosphopeptide-Dependent Labeling of 14-3-3[zeta] Proteins by Fusicoccin-Based Fluorescent Probes

Phosphopeptide-Dependent Labeling of 14-3-3[zeta] Proteins by Fusicoccin-Based Fluorescent Probes

Fluorescent combination: Cell-penetrating probes derived from the diterpene fusicoccin can form ternary complexes with 14-3-3 proteins and phosphopeptide ligands, whereupon the probes site-specifically attach a fluorescent tag onto the surface of the 14-3-3 proteins.

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Veröffentlicht in:Angewandte Chemie International Edition 2012-01, Vol.51 (2), p.509
Hauptverfasser: Takahashi, Michiko, Kawamura, Akie, Kato, Nobuo, Nishi, Tsuyoshi, Hamachi, Itaru, Ohkanda, Junko
Format: Artikel
Sprache:eng
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Zusammenfassung:Fluorescent combination: Cell-penetrating probes derived from the diterpene fusicoccin can form ternary complexes with 14-3-3 proteins and phosphopeptide ligands, whereupon the probes site-specifically attach a fluorescent tag onto the surface of the 14-3-3 proteins.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201106995