A Second-Generation Total Synthesis of SpirastrellolideA Methyl Ester

A Second-Generation Total Synthesis of SpirastrellolideA Methyl Ester

Marine macrolides: an improved second-generation total synthesis of the anticancer macrolide spirastrellolide A methyl ester has been achieved. The synthesis features a uniformly high level of stereocontrol combined with more expedient fragment assembly, and demonstrates a critical dependence of the...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-03, Vol.51 (11), p.2749
Hauptverfasser: Paterson, Ian, Maltas, Philip, Dalby, Stephen M, Lim, Jong Ho, Anderson, Edward A
Format: Artikel
Sprache:eng
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Zusammenfassung:Marine macrolides: an improved second-generation total synthesis of the anticancer macrolide spirastrellolide A methyl ester has been achieved. The synthesis features a uniformly high level of stereocontrol combined with more expedient fragment assembly, and demonstrates a critical dependence of the crucial macrolactonization step on the substitution pattern of the C22-C24 linker region.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201108594