pH-Tunable Calcium Phosphate Covered Mesoporous Silica Nanocontainers for Intracellular Controlled Release of Guest Drugs

pH-Tunable Calcium Phosphate Covered Mesoporous Silica Nanocontainers for Intracellular Controlled Release of Guest Drugs

Springing the trap: A pH‐responsive mesoporous silica nanoparticle with a calcium phosphate (CaP) pore‐blocking coating was developed by enzyme‐mediated surface mineralization under mild conditions. Upon exposure to cellular lysosomal pH, guest anticancer drug was released from the pore by dissoluti...

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Veröffentlicht in:Angewandte Chemie International Edition 2011-09, Vol.50 (38), p.8853-8857
Hauptverfasser: Rim, Hwa Pyeong, Min, Kyung Hyun, Lee, Hong Jae, Jeong, Seo Young, Lee, Sang Cheon
Format: Artikel
Sprache:eng
Schlagworte:
drug delivery
host-guest systems
mesoporous materials
mineralization
nanoparticles
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Beschreibung
Zusammenfassung:Springing the trap: A pH‐responsive mesoporous silica nanoparticle with a calcium phosphate (CaP) pore‐blocking coating was developed by enzyme‐mediated surface mineralization under mild conditions. Upon exposure to cellular lysosomal pH, guest anticancer drug was released from the pore by dissolution of the CaP pore blocker (see picture; HAp=hydroxyapatite).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201101536