Accelerated partial breast irradiation with external beam three-dimensional conformal radiotherapy: Five-year results of a prospective phase II clinical study

Purpose The aim of this study was to report the 5-year results of accelerated partial breast irradiation (APBI) using external beam three-dimensional conformal radiotherapy (3D-CRT). Patients and methods Between 2006 and 2011, 44 patients with low-risk, stage I–II breast cancer underwent breast-cons...

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Veröffentlicht in:Strahlentherapie und Onkologie 2014-05, Vol.190 (5), p.444-450
Hauptverfasser: Mózsa, Emöke, Mészáros, Norbert, Major, Tibor, Fröhlich, Georgina, Stelczer, Gábor, Sulyok, Zoltán, Fodor, János, Polgár, Csaba
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Sprache:eng
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Zusammenfassung:Purpose The aim of this study was to report the 5-year results of accelerated partial breast irradiation (APBI) using external beam three-dimensional conformal radiotherapy (3D-CRT). Patients and methods Between 2006 and 2011, 44 patients with low-risk, stage I–II breast cancer underwent breast-conserving surgery. Postoperative APBI was given by means of 3D-CRT using three to five non-coplanar fields. The total dose of APBI was 36.9 Gy (nine fractions of  4.1 Gy b.i.d.). The mean follow-up time was 58.2 months for surviving patients. Survival results, side effects, and cosmetic results were assessed. Results One (2.3 %) local recurrence was observed, for a 5-year actuarial rate of 3.7 %. Neither regional nor distant failure was observed. Two patients died of internal disease. The 5-year disease-free, cancer-specific, and overall survival rates were 96.3, 100, and 95.1 %, respectively. Acute side effects included grade 1 (G1) erythema in 75 %, G1 parenchymal induration in 46 %, and G1 pain in 46 % of patients. No G2 or higher acute side effect occurred. Late side effects included G1, G2, and G3 fibrosis in 44, 7, and 2 % of patients, respectively, G1 skin pigmentation in 12 %, and G1 pain in 2 %. Asymptomatic fat necrosis occurred in 14 %. Cosmetic results were rated excellent or good in 86 % of cases by the patients themselves and 84 % by the physicians. Conclusions The 5-year local tumor control, toxicity profile, and cosmetic results of APBI delivered with external beam 3D-CRT are encouraging and comparable to other APBI series.
ISSN:0179-7158
1439-099X
DOI:10.1007/s00066-014-0633-1