A New Approach to Forced Degradation Studies Using Anhydrous Conditions

In comparing the aqueous and anhydrous forceddegradation conditions for C1, a higher temperature was used to facilitate degradation under certain conditions to achieve the target degradation within a reasonable time. Different amounts of degradation for C1 were observed for both the aqueous and anhydrous studies, likely due to the type, strength and mechanism of acid, base, oxidative, or light mediated degradation.