Anti-GAD negative stiff person syndrome with a favorable response to intravenous methylprednisolone: an experience over evidence

Considering possibility of "stiff person syndrome" (SPS) both serum and cerebrospinal fluid samples were subjected to anti-glutamic acid decarboxylase (GAD) antibody testing; which were negative. Electromyography revealed presence of continuous motor unit activity in paraspinals, rectus ab...

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Veröffentlicht in:	Neurology India 2014-01, Vol.62 (1), p.76
Hauptverfasser:	Sharma, Bhawna, Nagpal, Kadam, Prakash, Swayam, Gupta, Pankaj
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Administration, Intravenous Aged Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Autoantibodies Case studies Diagnosis Dosage and administration Drug therapy Glutamate Decarboxylase Health aspects Humans Male Medical treatment Methylprednisolone Methylprednisolone - administration & dosage Methylprednisolone - pharmacology Muscular system Stiff-person syndrome Stiff-Person Syndrome - blood Stiff-Person Syndrome - cerebrospinal fluid Stiff-Person Syndrome - diagnosis Stiff-Person Syndrome - drug therapy Treatment Outcome
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Zusammenfassung:	Considering possibility of "stiff person syndrome" (SPS) both serum and cerebrospinal fluid samples were subjected to anti-glutamic acid decarboxylase (GAD) antibody testing; which were negative. Electromyography revealed presence of continuous motor unit activity in paraspinals, rectus abdominis [Figure 1]b and c, biceps brachii and vastus lateralis muscles with fasciculations and doublets seen in bilateral first dorsal interossei.
ISSN:	0028-3886 1998-4022
DOI:	10.4103/0028-3886.128332