Amphetamine-induced dopamine release: Duration of action as assessed by the dopamine-2-receptor (D2) agonist [11C]NPA in baboons

Amphetamine-induced dopamine release: Duration of action as assessed by the dopamine-2-receptor (D2) agonist [11C]NPA in baboons

[...]it is unknown whether such a temporal disconnect between microdialysis and radiotracer binding is a unique pharmacological characteristic of antagonist radiotracers or a property shared by agonist radiotracers as well. (-)-N-[11C]-Propyl-norapomorphine (NPA) is a full dopamine (DA) D2 receptor...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2006, Vol.31, p.T118-T118
Hauptverfasser: Narendran, Raj, Hwang, D.-R., Slifstein, M., Hwang, Y., Hackett, E., Sudeall, K., Castrillon, J., Laruelle, M.
Format: Artikel
Sprache:eng
Schlagworte:
Dopamine
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Zusammenfassung:[...]it is unknown whether such a temporal disconnect between microdialysis and radiotracer binding is a unique pharmacological characteristic of antagonist radiotracers or a property shared by agonist radiotracers as well. (-)-N-[11C]-Propyl-norapomorphine (NPA) is a full dopamine (DA) D2 receptor agonist radiotracer suitable for imaging D2 receptors configured in a state of high affinity for agonists (D2 high) with positron emission tomography (PET).
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.04.104