Reduced cerebral DOPA uptake in adult patients suffering from phenylketonuria

Reduced cerebral DOPA uptake in adult patients suffering from phenylketonuria

Aim: In phenylketonuria (PKU), the lack of phenylalanin-hydroxylase causes an excess of phenylalanine in all body compartments. Since phenylalanine and tyrosine compete for the same transport system in neurons, synthesizing dopamine from tyrosine in PKU patients with elevated phenylalanine values, a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2006, Vol.31, p.T171-T171
Hauptverfasser: Landvogt, Christian, Mengel, E., Buchholz, H.-G., Siessmeier, T., Zepp, F., Ullrich, K., Bartenstein, P.
Format: Artikel
Sprache:eng
Schlagworte:
Blood-brain barrier
Brain
Dopamine
Patients
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aim: In phenylketonuria (PKU), the lack of phenylalanin-hydroxylase causes an excess of phenylalanine in all body compartments. Since phenylalanine and tyrosine compete for the same transport system in neurons, synthesizing dopamine from tyrosine in PKU patients with elevated phenylalanine values, a decrease of dopamine levels can be expected.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.04.154