Impact of presynaptic dopamine activity on D1 radiotracer binding in vivo in rodent brain

Impact of presynaptic dopamine activity on D1 radiotracer binding in vivo in rodent brain

Discussion: The present results showed that AMPH produced significant increases in striatal D1 radioligand [3H]SCH 23390 and [11C]NNC 112 binding in vivo. Since AMPH induces D1 receptor internalization, these results are consistent with our previous finding that NMDA blockade-induced D1 internalizat...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2006, Vol.31, p.T115-T115
Hauptverfasser: Guo, Ningning, Hwang, D.-R., Slifstein, M., Quadri, N., Sudeall, K., Bialo, D., Hwang, Y., Laruelle, M.
Format: Artikel
Sprache:eng
Schlagworte:
Dopamine
Rodents
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Zusammenfassung:Discussion: The present results showed that AMPH produced significant increases in striatal D1 radioligand [3H]SCH 23390 and [11C]NNC 112 binding in vivo. Since AMPH induces D1 receptor internalization, these results are consistent with our previous finding that NMDA blockade-induced D1 internalization resulted an increased D1 in vivo binding in rodent brain (1).
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.04.101