Relationship between serotonin-1A binding and HPA axis in subjects with major depression and healthy controls

Relationship between serotonin-1A binding and HPA axis in subjects with major depression and healthy controls

Preclinical evidence of tonic inhibition of 5HT1A expression by excessive glucocorticoid receptor stimulation, particularly in the hippocampus, suggests a link between the serotonergic system and HPA axis hyperactivity in the pathophysiology of depression. Post-hoc analyses assessed binding in secon...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2008, Vol.41, p.T146-T146
Hauptverfasser: Carlson, Paul J., Bain, E., Tinsley, R., Nugent, A., Carson, R., Luckenbaugh, D., Kling, M., Gold, P., Remaley, A., Drevets, W.C.
Format: Artikel
Sprache:eng
Schlagworte:
Hypotheses
Plasma
Stress
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Zusammenfassung:Preclinical evidence of tonic inhibition of 5HT1A expression by excessive glucocorticoid receptor stimulation, particularly in the hippocampus, suggests a link between the serotonergic system and HPA axis hyperactivity in the pathophysiology of depression. Post-hoc analyses assessed binding in secondary ROIs in anterior cingulate cortex (ACC), anterior insula (AI), and posterior cingulate (PC).
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2008.04.114