Within-subject comparison of the sensitivity of [11C]-(+)-PHNO and [11C]raclopride to amphetamine induced changes in endogenous dopamine in healthy human volunteers

Dynamic PET emission data was acquired over 90min, regions of interest (ROI) delineated on individual subjects' structural MRI and applied to the dynamic PET to generate regional time-activity-curves (rTACs). Comparison of the effects of amphetamine in these ROI, by using a high affinity D2/D3 antagonist radioligand such as [18F]fallypride or [11C]FLB-457, should allow direct comparisons of the sensitivity of D3 and D2 receptors to detect fluctuations in endogenous dopamine.