Decreased P-glycoprotein function at the blood–brain barrier in patients with Alzheimer's disease as shown by (R)-[11C]verapamil and PET

Decreased P-glycoprotein function at the blood–brain barrier in patients with Alzheimer's disease as shown by (R)-[11C]verapamil and PET

Methods: Dynamic (R)-[11C]verapamil PET scans with full arterial blood sampling were performed in 13 AD patients and 15 age matched HC.

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2010-08, Vol.52 (S1), p.S53-S53
Hauptverfasser: van Assema, Danielle M.E., Lubberink, Mark, Hoetjes, Nikie J., Hendrikse, Harry H., Schuit, Robert C., Windhorst, Albert D., der Flier, Wiesje M. van, Scheltens, Philip, Lammertsma, Adriaan A., van Berckel, Bart N.M.
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
Blood
Blood-brain barrier
Medical research
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Zusammenfassung:Methods: Dynamic (R)-[11C]verapamil PET scans with full arterial blood sampling were performed in 13 AD patients and 15 age matched HC.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.04.234