The novel mGluR5 radioligand [11C]AZ11696415: Palladium mediated11C-cyanation and initial in vivo characterization in the cynomolgus monkey brain using positron emission tomography (PET)

The novel mGluR5 radioligand [11C]AZ11696415: Palladium mediated11C-cyanation and initial in vivo characterization in the cynomolgus monkey brain using positron emission tomography (PET)

Introduction: The mGluR5 is believed to be an important therapeutic target for a number of CNS disorders including anxiety, schizophrenia, Parkinson's disease, addiction, epilepsy as well as various pain states.

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2010-08, Vol.52 (S1), p.S122-S122
Hauptverfasser: Andersson, Jan, Seneca, Nicholas, Truong, Phong, Wensbo, David, McLeod, Donald, Raboisson, Patrick, Farde, Lars, Halldin, Christer
Format: Artikel
Sprache:eng
Schlagworte:
Ligands
Radioactivity
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Zusammenfassung:Introduction: The mGluR5 is believed to be an important therapeutic target for a number of CNS disorders including anxiety, schizophrenia, Parkinson's disease, addiction, epilepsy as well as various pain states.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.04.100