TCT-744 Double (360mg) Loading Dose Of Ticagrelor In Patients With ST-elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

TCT-744 Double (360mg) Loading Dose Of Ticagrelor In Patients With ST-elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Background In patients with ST elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) ticagrelor 180mg loading dose (LD) exhibits a delayed onset of action - from what would be predicted based on assessments in stable patients. Since Cmax for ticagrelor...

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Veröffentlicht in:Journal of the American College of Cardiology 2012-10, Vol.60 (17), p.B217-B217
Hauptverfasser: Alexopoulos, Dimitrios, Xanthopoulou, Ioanna, Gkizas, Vassilios, Kassimis, George, Theodoropoulos, Konstantinos, Grigorios, Tsigkas, Chiladakis, Ioannis, Damelou, Anastasia, Hahalis, George, Davlouros, Periklis
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiovascular
Drug therapy
Heart attacks
Internal Medicine
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Zusammenfassung:Background In patients with ST elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) ticagrelor 180mg loading dose (LD) exhibits a delayed onset of action - from what would be predicted based on assessments in stable patients. Since Cmax for ticagrelor and its main metabolite increases approximately dose-proportionately, we hypothesized that doubling the ticagrelor LD in patients with STEMI undergoing pPCI may lead to faster early platelet inhibition.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2012.08.785