Mechanical Valve Thrombosis With Dabigatran

Case 2 A 59-year-old female with a prior mechanical mitral valve replacement presented for routine follow-up. Since her valve replacement for rheumatic mitral disease in 2007, the patient had been treated with warfarin without complication. Regulatory approval was based on the pivotal RE-L-Y (Random...

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Veröffentlicht in:	Journal of the American College of Cardiology 2012-10, Vol.60 (17), p.1710-1711
Hauptverfasser:	Price, Joel, MD, MPH, Hynes, Mark, MD, Labinaz, Marino, MD, Ruel, Marc, MD, MPH, Boodhwani, Munir, MD, MMSC
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants Antithrombins - therapeutic use Benzimidazoles - therapeutic use beta-Alanine - analogs & derivatives beta-Alanine - therapeutic use Blood clots Cardiology Cardiovascular Dabigatran Diagnosis, Differential Drug therapy Echocardiography, Transesophageal Female Follow-Up Studies Heart Diseases - diagnosis Heart Diseases - drug therapy Heart Diseases - etiology Heart Valve Diseases - surgery Heart Valve Prosthesis - adverse effects Humans Internal Medicine Middle Aged Patients Prostheses Prosthesis Failure Regulatory approval Studies Thrombosis Thrombosis - diagnosis Thrombosis - drug therapy Thrombosis - etiology Ultrasonic imaging
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Beschreibung
Zusammenfassung:	Case 2 A 59-year-old female with a prior mechanical mitral valve replacement presented for routine follow-up. Since her valve replacement for rheumatic mitral disease in 2007, the patient had been treated with warfarin without complication. Regulatory approval was based on the pivotal RE-L-Y (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial, which compared dabigatran to warfarin for the treatment of nonvalvular AF (2).
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2012.06.039