Highlights of the Year in JACC 2007

Interventional Cardiology First Reports of New Randomized Clinical Trials Unprotected left main coronary artery intervention The role of percutaneous coronary intervention (PCI) in unprotected left main coronary artery stenosis in the current era is not well defined. In an elegant series of experime...

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Veröffentlicht in:Journal of the American College of Cardiology 2008-01, Vol.51 (4), p.490-512
Hauptverfasser: DeMaria, Anthony N., MD, MACC, Bax, Jeroen J., MD, PhD, FACC, Ben-Yehuda, Ori, MD, FACC, Clopton, Paul, MS, Feld, Gregory K., MD, FACC, Ginsburg, Geoffrey S., MD, PhD, FACC, Greenberg, Barry H., MD, FACC, Knoke, James D., PhD, Lew, Wilbur Y.W., MD, FACC, Lima, João A.C., MD, FACC, Maisel, Alan S., MD, FACC, Narayan, Sanjiv M., MD, FACC, Narula, Jagat, MD, PhD, FACC, Sahn, David J., MD, MACC, Tsimikas, Sotirios, MD, FACC
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Sprache:eng
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Zusammenfassung:Interventional Cardiology First Reports of New Randomized Clinical Trials Unprotected left main coronary artery intervention The role of percutaneous coronary intervention (PCI) in unprotected left main coronary artery stenosis in the current era is not well defined. In an elegant series of experiments, they report the novel finding that DCM-IgG-F(ab')2 bind to cardiac antigens and that their Fc portion when bound to a novel Fc gamma receptor on cardiomyocytes results in a negative inotropic effect. [...]Fc gamma receptors may have a role in DCM and other immune-mediated cardiac diseases.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.12.003