Ethanol Abolishes Ischemic Preconditioning in Humans

Ethanol Abolishes Ischemic Preconditioning in Humans

Ethanol Abolishes Ischemic Preconditioning in Humans Giampaolo Niccoli, Luca Altamura, Alessandro Fabretti, Gaetano A. Lanza, Luigi M. Biasucci, Antonio G. Rebuzzi, Antonio Maria Leone, Italo Porto, Francesco Burzotta, Carlo Trani, Filippo Crea Ischemic preconditioning (IPC) is the most potent form...

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Veröffentlicht in:Journal of the American College of Cardiology 2008-01, Vol.51 (3), p.271-275
Hauptverfasser: Niccoli, Giampaolo, MD, PhD, Altamura, Luca, MD, Fabretti, Alessandro, MD, Lanza, Gaetano A., MD, Biasucci, Luigi M., MD, Rebuzzi, Antonio G., MD, Leone, Antonio Maria, MD, Porto, Italo, MD, PhD, Burzotta, Francesco, MD, PhD, Trani, Carlo, MD, Crea, Filippo, MD, FACC
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Angina Pectoris - physiopathology
Angina Pectoris - therapy
Angioplasty, Balloon, Coronary
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular
Coronary vessels
Ethanol - adverse effects
Ethanol - blood
Gin
Heart attacks
Humans
Internal Medicine
Ischemia
Ischemic Preconditioning, Myocardial
Male
Medical sciences
Middle Aged
Mortality
Myocardial Ischemia - chemically induced
Myocardial Ischemia - physiopathology
Prospective Studies
Veins & arteries
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Zusammenfassung:Ethanol Abolishes Ischemic Preconditioning in Humans Giampaolo Niccoli, Luca Altamura, Alessandro Fabretti, Gaetano A. Lanza, Luigi M. Biasucci, Antonio G. Rebuzzi, Antonio Maria Leone, Italo Porto, Francesco Burzotta, Carlo Trani, Filippo Crea Ischemic preconditioning (IPC) is the most potent form of endogenous myocardial protection from irreversible ischemic injury. Experimental observations suggest that acute ethanol administration might abolish IPC. We randomized 30 patients to oral gin or water before angioplasty to assess the effect of alcohol intake on IPC in humans. We evaluated ST-segment shift by intracoronary electrocardiogram during 2 sequential balloon inflations. We show that administration of a moderate dose of ethanol abolishes IPC occurring during sequential episodes of myocardial ischemia and is associated with worsening ischemia.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.09.042