T Cells in Coronary Artery Disease: Different Effects of Different T-Cell SubsetsEditorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology

[...]monocytes from patients with unstable angina exhibit a molecular fingerprint of a recent IFN-γ triggering, and such patients also have raised plasma levels of IL-18 that significantly correlated with the degree of myocardial dysfunction, further implicating TH1-mediated immune responses in the pathogenesis of acute coronary syndromes (ACS) (9). [...]transforming growth factor (TGF)-β, another T-cell-derived antiinflammatory cytokine, has been shown to possess potent antiatherogenic properties. [...]when apoE-knockout mice were crossed with transgenic mice carrying a dominant negative TGF-β receptor II in T cells, the offspring developed markedly increased atherosclerosis with larger and more unstable lesions (2).