Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis

Abstract The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its mu...

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Veröffentlicht in:	Cancer letters 2010-03, Vol.289 (1), p.11-22
Hauptverfasser:	Martin-Kleiner, Irena, Gall Troselj, Koraljka
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cancer Cell growth Genes Genes, Tumor Suppressor Genetic Predisposition to Disease Hematology, Oncology and Palliative Medicine Humans IGF2 Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Loss of heterozygosity M6P/IGF2R Molecular Sequence Data Mutation Neoplasms - physiopathology Receptor, IGF Type 2 - genetics Receptor, IGF Type 2 - metabolism Rodents
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