Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis

Abstract The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its mu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2010-03, Vol.289 (1), p.11-22
Hauptverfasser:	Martin-Kleiner, Irena, Gall Troselj, Koraljka
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cancer Cell growth Genes Genes, Tumor Suppressor Genetic Predisposition to Disease Hematology, Oncology and Palliative Medicine Humans IGF2 Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Loss of heterozygosity M6P/IGF2R Molecular Sequence Data Mutation Neoplasms - physiopathology Receptor, IGF Type 2 - genetics Receptor, IGF Type 2 - metabolism Rodents
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its multifunctionality, it is not easy to understand the extent of its relevance to normal cellular physiology. Accordingly, it is even more difficult understanding its role in carcinogenesis. This review presents critical and focused highlights of data relating to M6P/IGF2R, obtained during more than 25 years of cancer research.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2009.06.036