Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis
Abstract The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its mu...
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| Veröffentlicht in: | Cancer letters 2010-03, Vol.289 (1), p.11-22 |
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| container_title | Cancer letters |
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| creator | Martin-Kleiner, Irena Gall Troselj, Koraljka |
| description | Abstract The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its multifunctionality, it is not easy to understand the extent of its relevance to normal cellular physiology. Accordingly, it is even more difficult understanding its role in carcinogenesis. This review presents critical and focused highlights of data relating to M6P/IGF2R, obtained during more than 25 years of cancer research. |
| doi_str_mv | 10.1016/j.canlet.2009.06.036 |
| format | Article |
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It is involved in a variety of cellular processes which become dysregulated in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its multifunctionality, it is not easy to understand the extent of its relevance to normal cellular physiology. Accordingly, it is even more difficult understanding its role in carcinogenesis. This review presents critical and focused highlights of data relating to M6P/IGF2R, obtained during more than 25 years of cancer research.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2009.06.036</identifier><identifier>PMID: 19646808</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Amino Acid Sequence ; Animals ; Cancer ; Cell growth ; Genes ; Genes, Tumor Suppressor ; Genetic Predisposition to Disease ; Hematology, Oncology and Palliative Medicine ; Humans ; IGF2 ; Insulin-Like Growth Factor II - genetics ; Insulin-Like Growth Factor II - metabolism ; Loss of heterozygosity ; M6P/IGF2R ; Molecular Sequence Data ; Mutation ; Neoplasms - physiopathology ; Receptor, IGF Type 2 - genetics ; Receptor, IGF Type 2 - metabolism ; Rodents</subject><ispartof>Cancer letters, 2010-03, Vol.289 (1), p.11-22</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2009 Elsevier Ireland Ltd</rights><rights>Copyright 2009 Elsevier Ireland Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Mar 1, 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-8033b2441fe85ab4c06a2cc1f061a6d16db5b1efe8116d8e96ef51046e5c22c3</citedby><cites>FETCH-LOGICAL-c444t-8033b2441fe85ab4c06a2cc1f061a6d16db5b1efe8116d8e96ef51046e5c22c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2009.06.036$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19646808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin-Kleiner, Irena</creatorcontrib><creatorcontrib>Gall Troselj, Koraljka</creatorcontrib><title>Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Abstract The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. 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This review presents critical and focused highlights of data relating to M6P/IGF2R, obtained during more than 25 years of cancer research.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Cancer</subject><subject>Cell growth</subject><subject>Genes</subject><subject>Genes, Tumor Suppressor</subject><subject>Genetic Predisposition to Disease</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>IGF2</subject><subject>Insulin-Like Growth Factor II - genetics</subject><subject>Insulin-Like Growth Factor II - metabolism</subject><subject>Loss of heterozygosity</subject><subject>M6P/IGF2R</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Neoplasms - physiopathology</subject><subject>Receptor, IGF Type 2 - genetics</subject><subject>Receptor, IGF Type 2 - metabolism</subject><subject>Rodents</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFr3DAQhUVpaTZJ_0Ephl7Sg70jWdLKl0IITRpISEgDPQpZHme1cSRH8rbk30dmFwK99DQD8-YN7xtCPlOoKFC53FTW-AGnigE0FcgKavmOLKhasXLVKHhPFlADL2tViwNymNIGAARfiY_kgDaSSwVqQX5fG-9DwlKW4zqkcW0mXDqftoPz5eAesXiI4e-0LnpjpxALVkS0OM7tybW8XV5enLO7b4XzhTXROh8e0GNy6Zh86M2Q8NO-HpH78x_3Zz_Lq5uLy7PTq9JyzqdSQV23jHPaoxKm5RakYdbSHiQ1sqOya0VLMU9p7hU2EntBgUsUljFbH5GvO9sxhuctpklvwjb6fFFTARKEVFxlFd-pbAwpRez1GN2TiS-agp5h6o3ewdQzTA1SZ5h57cvefNs-Yfe2tKeXBd93AswJ_ziMOlmH3mLnMqVJd8H978K_BjZzd9YMj_iC6S2LTkyD_jU_dP4nNJAZ8KZ-BVG4muo</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Martin-Kleiner, Irena</creator><creator>Gall Troselj, Koraljka</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20100301</creationdate><title>Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis</title><author>Martin-Kleiner, Irena ; Gall Troselj, Koraljka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-8033b2441fe85ab4c06a2cc1f061a6d16db5b1efe8116d8e96ef51046e5c22c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Cancer</topic><topic>Cell growth</topic><topic>Genes</topic><topic>Genes, Tumor Suppressor</topic><topic>Genetic Predisposition to Disease</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>IGF2</topic><topic>Insulin-Like Growth Factor II - genetics</topic><topic>Insulin-Like Growth Factor II - metabolism</topic><topic>Loss of heterozygosity</topic><topic>M6P/IGF2R</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Neoplasms - physiopathology</topic><topic>Receptor, IGF Type 2 - genetics</topic><topic>Receptor, IGF Type 2 - metabolism</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin-Kleiner, Irena</creatorcontrib><creatorcontrib>Gall Troselj, Koraljka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin-Kleiner, Irena</au><au>Gall Troselj, Koraljka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>289</volume><issue>1</issue><spage>11</spage><epage>22</epage><pages>11-22</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Abstract The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. 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| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2010-03, Vol.289 (1), p.11-22 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amino Acid Sequence Animals Cancer Cell growth Genes Genes, Tumor Suppressor Genetic Predisposition to Disease Hematology, Oncology and Palliative Medicine Humans IGF2 Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Loss of heterozygosity M6P/IGF2R Molecular Sequence Data Mutation Neoplasms - physiopathology Receptor, IGF Type 2 - genetics Receptor, IGF Type 2 - metabolism Rodents |
| title | Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis |
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