Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development

The chemopreventive activity of methanolic extract of Apium graveolens seeds (celery seeds) has been investigated against Solt Farber protocol of hepatocarcinogenesis, oxidative stress and induction of positive foci of γ-GT in the liver of Wistar rats. The prophylactic treatment of celery seeds extr...

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Veröffentlicht in:	Cancer letters 2005-04, Vol.221 (1), p.11-20
Hauptverfasser:	Sultana, Sarwat, Ahmed, Salahuddin, Jahangir, Tamanna, Sharma, Sonia
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Acetylaminofluorene A. graveolens Animals Anticarcinogenic Agents - pharmacology Apium graveolens Cancer Cell growth Cell Proliferation - drug effects Chemoprevention Deoxyribonucleic acid Diethylnitrosamine DNA Enzymes gamma-Glutamyltransferase - metabolism Hepatocarcinoma Herbal medicine Liver - drug effects Liver - enzymology Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - prevention & control Metabolism Plant Extracts - pharmacology Polyamines Rats Rats, Wistar Rodents Seeds Studies
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Zusammenfassung:	The chemopreventive activity of methanolic extract of Apium graveolens seeds (celery seeds) has been investigated against Solt Farber protocol of hepatocarcinogenesis, oxidative stress and induction of positive foci of γ-GT in the liver of Wistar rats. The prophylactic treatment of celery seeds extract protected dose dependently against diethylnitrosoamine (DEN)+2-acetylaminofluorine (AAF)+partial hepatectomy (PH) induced hepatocarcinogenesis and other related events such as induction of γ-GT positive foci ( P
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2004.07.030