Effect of combined photodynamic and chemotherapeutic treatment on lymphoma cells in vitro

We investigated the cytotoxic and apoptotic effects of a combination of photodynamic therapy (PDT) and cisplatin (CDDP) on L5178Y (LY) cells. Treatment with PDT by photofrin ® (5 μg/ml) alone or with CDDP (20 μg/ml) alone killed 41.5±8.5% or 42.9±6.5% of LY cells, respectively, while a combination o...

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Veröffentlicht in:	Cancer letters 2002-10, Vol.184 (2), p.171-178
Hauptverfasser:	Nonaka, M, Ikeda, H, Inokuchi, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - toxicity Apoptosis Apoptosis - drug effects Biological and medical sciences Cancer Cancer therapies Cell cycle Cell Survival - drug effects Cisplatin Cisplatin - toxicity Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Cytotoxicity Dentistry Deoxyribonucleic acid Dihematoporphyrin Ether - toxicity DNA Drug dosages Humans Medical sciences Pharmacology. Drug treatments Photochemotherapy Photodynamic therapy Photofrin Tumor Cells, Cultured
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Zusammenfassung:	We investigated the cytotoxic and apoptotic effects of a combination of photodynamic therapy (PDT) and cisplatin (CDDP) on L5178Y (LY) cells. Treatment with PDT by photofrin ® (5 μg/ml) alone or with CDDP (20 μg/ml) alone killed 41.5±8.5% or 42.9±6.5% of LY cells, respectively, while a combination of these two treatments killed 99.7±0.6%. Apoptotic cell death after combination treatment was also revealed to be 49.6±7.8% compared to 12.4±3.4% after PDT alone, and 18.8±2.6% after CDDP. This study demonstrated that combined treatment of PDT and CDDP results in enhanced apoptotic cell death as well as a cytotoxic effect on LY cells.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/S0304-3835(02)00208-2