Box 1. Example: A strongly coupled network comprising three interacting molecular species (genes)

Box 1. Example: A strongly coupled network comprising three interacting molecular species (genes)

Networks and pathways are usually regulated and controlled by feedback and feed-forward control - whether the directional behaviors are well understood or not. The consequences and practical opportunities of characterizing and elucidating networks offer enormous potential for biology, medicine and b...

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Veröffentlicht in:Trends in biotechnology (Regular ed.) 2002-11, Vol.20 (11), p.445
Hauptverfasser: Greller, Larry D, Somogyi, Roland
Format: Artikel
Sprache:eng
Schlagworte:
Behavior
Biology
Biotechnology
Data mining
Discipline
Disease
Gene expression
Methods
Principal components analysis
Proteins
Reverse engineering
Sparsity
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Zusammenfassung:Networks and pathways are usually regulated and controlled by feedback and feed-forward control - whether the directional behaviors are well understood or not. The consequences and practical opportunities of characterizing and elucidating networks offer enormous potential for biology, medicine and biotechnology. The recent paper by Yeunget al.stands as a fine example of practical reverse engineering method.
ISSN:0167-7799
1879-3096
DOI:10.1016/S0167-7799(02)02051-6