The response of mouse embryonic stem cells to low doses of [gamma]-radiation: Evidence for an adaptive response

The response of mouse embryonic stem cells to low doses of [gamma]-radiation: Evidence for an adaptive response

Low doses of ionizing radiation may induce an adaptive mechanism which protects embryonic stem cells against higher doses, a phenomenon which was reported previously for somatic cells. In this study, a possible adaptive response (AR) was evaluated by measuring cell survival (MTT assay) and chromosom...

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Veröffentlicht in:Mutation research. Genetic toxicology and environmental mutagenesis 2014-02, Vol.761, p.44
Hauptverfasser: Kalantari, Hamid, Motamed, Nasrin, Meybodi, Anahita Mohseni, Arfaie, Ali Jabbari, Baharvand, Hossein, Gourabi, Hamid
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Bioassays
Radiation
Rodents
Stem cells
Stress response
Survival analysis
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container_title Mutation research. Genetic toxicology and environmental mutagenesis
container_volume 761
creator Kalantari, Hamid
Motamed, Nasrin
Meybodi, Anahita Mohseni
Arfaie, Ali Jabbari
Baharvand, Hossein
Gourabi, Hamid
description Low doses of ionizing radiation may induce an adaptive mechanism which protects embryonic stem cells against higher doses, a phenomenon which was reported previously for somatic cells. In this study, a possible adaptive response (AR) was evaluated by measuring cell survival (MTT assay) and chromosomal aberrations (micronucleus assay). Thymidine-synchronized mouse embryonic stem cells (mESCs) were exposed to 2.5, 3.7, or 5 cGy ...Co ...-rays and, after 5 h challenged by a dose of 150 cGy. mESCs pre-irradiated at 2.5 cGy showed an adaptive response. (ProQuest: ... denotes formulae/symbols omitted.)
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1879-3592
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source Elsevier ScienceDirect Journals
subjects Bioassays
Radiation
Rodents
Stem cells
Stress response
Survival analysis
title The response of mouse embryonic stem cells to low doses of [gamma]-radiation: Evidence for an adaptive response
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