The response of mouse embryonic stem cells to low doses of [gamma]-radiation: Evidence for an adaptive response

The response of mouse embryonic stem cells to low doses of [gamma]-radiation: Evidence for an adaptive response

Low doses of ionizing radiation may induce an adaptive mechanism which protects embryonic stem cells against higher doses, a phenomenon which was reported previously for somatic cells. In this study, a possible adaptive response (AR) was evaluated by measuring cell survival (MTT assay) and chromosom...

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Veröffentlicht in:Mutation research. Genetic toxicology and environmental mutagenesis 2014-02, Vol.761, p.44
Hauptverfasser: Kalantari, Hamid, Motamed, Nasrin, Meybodi, Anahita Mohseni, Arfaie, Ali Jabbari, Baharvand, Hossein, Gourabi, Hamid
Format: Artikel
Sprache:eng
Schlagworte:
Bioassays
Radiation
Rodents
Stem cells
Stress response
Survival analysis
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Zusammenfassung:Low doses of ionizing radiation may induce an adaptive mechanism which protects embryonic stem cells against higher doses, a phenomenon which was reported previously for somatic cells. In this study, a possible adaptive response (AR) was evaluated by measuring cell survival (MTT assay) and chromosomal aberrations (micronucleus assay). Thymidine-synchronized mouse embryonic stem cells (mESCs) were exposed to 2.5, 3.7, or 5 cGy ...Co ...-rays and, after 5 h challenged by a dose of 150 cGy. mESCs pre-irradiated at 2.5 cGy showed an adaptive response. (ProQuest: ... denotes formulae/symbols omitted.)
ISSN:1383-5718
1879-3592