The Effect of Protein Binding on Adrenal Suppression Potential of Inhaled Corticosteroids

The Effect of Protein Binding on Adrenal Suppression Potential of Inhaled Corticosteroids

An integrated pharmacokinetic/pharmacodynamic model based on the circadian rhythm of cortisol secretion was developed to accurately predict ICS-related cortisol suppression (% decrease in 24h cortisol area under the curve) using individual pharmacokinetic profiles and relative receptor binding affin...

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Veröffentlicht in:Journal of allergy and clinical immunology 2006-02, Vol.117 (2), p.S94-S94
Hauptverfasser: Derendorf, H., Hochhaus, G.
Format: Artikel
Sprache:eng
Schlagworte:
Fluorescence
Hormones
Proteins
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Beschreibung
Zusammenfassung:An integrated pharmacokinetic/pharmacodynamic model based on the circadian rhythm of cortisol secretion was developed to accurately predict ICS-related cortisol suppression (% decrease in 24h cortisol area under the curve) using individual pharmacokinetic profiles and relative receptor binding affinities.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2005.12.376