CD4+ Foxp3+ CD127+low T-Regulatory Cells are Increased in HPV Infected Papillomas in Patients with Recurrent Respiratory Papillomatosis (RRP)

CD4+ Foxp3+ CD127+low T-Regulatory Cells are Increased in HPV Infected Papillomas in Patients with Recurrent Respiratory Papillomatosis (RRP)

Conclusion T-regs are increased in papillomas of RRP patients, compared to autologous PBMC, thus suggesting the dysregulation of T-cell responses to HPV may be influenced by T-regs. [...]the larger imbalance of T-regs in papillomas vs. the PBMC may influence disease severity.

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Veröffentlicht in:Journal of allergy and clinical immunology 2008-02, Vol.121 (2), p.S211-S211
Hauptverfasser: Hatam, L.J, Rosenthal, D.W, DeVoti, J.A, Lam, F, Abramson, A, Steinberg, B.M, Bonagura, V.R
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Human papillomavirus
T cell receptors
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Zusammenfassung:Conclusion T-regs are increased in papillomas of RRP patients, compared to autologous PBMC, thus suggesting the dysregulation of T-cell responses to HPV may be influenced by T-regs. [...]the larger imbalance of T-regs in papillomas vs. the PBMC may influence disease severity.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2007.12.789