Synergistic Induction of IL-23 Expression in Fibroblast-like Synoviocytes by IL-17 and TNF-Alpha: A Positive Feedback Loop in Rheumatoid Arthritis

Synergistic Induction of IL-23 Expression in Fibroblast-like Synoviocytes by IL-17 and TNF-Alpha: A Positive Feedback Loop in Rheumatoid Arthritis

Conclusions TNFα and IL-17 synergistically induce IL-23 expression in FLS. Since IL-23 induces the differentiation of naive T cells into Th17 cells with the subsequent generation of both TNFα and IL-17, this positive feedback loop helps explain the cascading unrelenting chronic inflammatory proces...

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Veröffentlicht in:Journal of allergy and clinical immunology 2008-02, Vol.121 (2), p.S134-S134
Hauptverfasser: Goldberg, M, Nadiv, O, Luknar-Gabor, N, Koch, P, Katz, Y
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
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Medical research
Rheumatoid arthritis
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Zusammenfassung:Conclusions TNFα and IL-17 synergistically induce IL-23 expression in FLS. Since IL-23 induces the differentiation of naive T cells into Th17 cells with the subsequent generation of both TNFα and IL-17, this positive feedback loop helps explain the cascading unrelenting chronic inflammatory process in rheumatoid arthritis.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2007.12.534