Effect of Treatment with Montelukast on Otitis Media (OM) in Children

Effect of Treatment with Montelukast on Otitis Media (OM) in Children

Animal studies have shown that instillation of leukotrienes into the middle ear results in the development of OM and that treatment with a leukotriene modifier results in resolution of OM. Since these results suggest that locally produced leukotrienes may play a role in the pathogenesis of OM, we hy...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology 2007, Vol.119 (1), p.S303-S303
Hauptverfasser: Gentile, D.A, Koehrsen, J.M, Skoner, D.P, Patel, A, Varga, M, Schad, C.A, Schaffner, T.J
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Ear diseases
Vaccines
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Animal studies have shown that instillation of leukotrienes into the middle ear results in the development of OM and that treatment with a leukotriene modifier results in resolution of OM. Since these results suggest that locally produced leukotrienes may play a role in the pathogenesis of OM, we hypothesized that treatment with montelukast would result in less recurrence of OM in susceptible children.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2006.12.559