Leukotriene E4 (LTE4 ) Is More Potent Than LTD4 For Inducing Cytokine Generation And Proliferation Of Human Mast Cells

Leukotriene E4 (LTE4 ) Is More Potent Than LTD4 For Inducing Cytokine Generation And Proliferation Of Human Mast Cells

Unlike cys-LT-mediated calcium flux, LTD4/LTE4-induced ERK phosphorylation was not blocked by MK571. [...]LTE4-induced ERK activation was not susceptible to interference by inhibitors of phosphoinositol-3-kinase (PI3K), whereas LTD4-induced ERK activation depended on PI3K.

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Veröffentlicht in:Journal of allergy and clinical immunology 2007, Vol.119 (1), p.S53-S53
Hauptverfasser: Paruchuri, S, Boyce, J.A
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Cytokines
Phosphorylation
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Zusammenfassung:Unlike cys-LT-mediated calcium flux, LTD4/LTE4-induced ERK phosphorylation was not blocked by MK571. [...]LTE4-induced ERK activation was not susceptible to interference by inhibitors of phosphoinositol-3-kinase (PI3K), whereas LTD4-induced ERK activation depended on PI3K.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2006.11.228