TLR2 Activation By Supernatant From Bifidobacterium Breve Modulates Maturation And Survival Of Human DCs Via Differential Effects On PI3Kinase, p38 And ERK Pathways

TLR2 Activation By Supernatant From Bifidobacterium Breve Modulates Maturation And Survival Of Human DCs Via Differential Effects On PI3Kinase, p38 And ERK Pathways

LY294002 kinase inhibitor revealed that PI3K/Akt pathway was preferentially involved for DCs survival after engagement by BbC50sn. [...]p38 inhibitor decreased DCs maturation after stimulation by both BbC50sn and LPS, but not DCs survival.

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Veröffentlicht in:Journal of allergy and clinical immunology 2007, Vol.119 (1), p.S258-S258
Hauptverfasser: Hoarau, C, Martin, L, Velge-roussel, F, Gontier, C, Lebranchu, Y
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Kinases
Phosphorylation
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Zusammenfassung:LY294002 kinase inhibitor revealed that PI3K/Akt pathway was preferentially involved for DCs survival after engagement by BbC50sn. [...]p38 inhibitor decreased DCs maturation after stimulation by both BbC50sn and LPS, but not DCs survival.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2006.12.377