Immunomodulatory Effects of Allergen-specific Sublingual Immunotherapy in a Rat Model of Allergic Sensitization

Immunomodulatory Effects of Allergen-specific Sublingual Immunotherapy in a Rat Model of Allergic Sensitization

Rats in the SRW-SLIT group had significantly lower levels of total and SRW-specific IgE and significantly higher levels of SRW-specific IgG1 (a rat IgG isotype associated with Th2 responses) and mediastinal lymph node Foxp3 mRNA expression (a specific Treg cell marker) than did rats in the sham-SLIT...

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Veröffentlicht in:Journal of allergy and clinical immunology 2007, Vol.119 (1), p.S310-S310
Hauptverfasser: Rosenthal, L.A, Su, X, Szakaly, R.J, Sorkness, R.L
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Medical research
Rodents
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Zusammenfassung:Rats in the SRW-SLIT group had significantly lower levels of total and SRW-specific IgE and significantly higher levels of SRW-specific IgG1 (a rat IgG isotype associated with Th2 responses) and mediastinal lymph node Foxp3 mRNA expression (a specific Treg cell marker) than did rats in the sham-SLIT group (P = 0.021).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2006.12.584