Airway Fibroblasts Isolated from Mouse Model of Allergic Asthma Display Distinct Cellular and Phenotypic Characteristics as Compared to Normal Fibroblasts

Airway Fibroblasts Isolated from Mouse Model of Allergic Asthma Display Distinct Cellular and Phenotypic Characteristics as Compared to Normal Fibroblasts

Airway fibroblasts from asthmatic mice displayed significant increase in collagen gel contraction ability, chemotactic activity, α-SMA expression, and growth factors (TGF-β1, VEGF, fibronectin) release in comparison to control mice. [...]fibroblasts from asthmatic mice proliferated at more than tw...

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Veröffentlicht in:Journal of allergy and clinical immunology 2007, Vol.119 (1), p.S301-S301
Hauptverfasser: Berro, A.I, Sugiura, H, Liu, X, Duan, F, Kawasaki, S, Togo, S, Kamio, K, Wang, X.Q, Mao, L, Ahn, Y, Ertl, R.F, Casale, T.B, Rennard, S.I
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Asthma
Gene expression
Rodents
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Zusammenfassung:Airway fibroblasts from asthmatic mice displayed significant increase in collagen gel contraction ability, chemotactic activity, α-SMA expression, and growth factors (TGF-β1, VEGF, fibronectin) release in comparison to control mice. [...]fibroblasts from asthmatic mice proliferated at more than twice the doubling rate of fibroblasts from control mice.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2006.12.547