Cutaneous CpG Administration Reduces Th2-type Airway Inflammation But Induces Airway Hyperreactivity

Cutaneous CpG Administration Reduces Th2-type Airway Inflammation But Induces Airway Hyperreactivity

Expression of regulatory cytokines TGF-β and IL-10 and, Foxp3, a specific marker for regulatory T cells, was significantly enhanced in the airways of CpG treated mice. [...]the levels of NRL-specific IgE were reduced and NRL-specific IgG2a levels were increased in NRL sensitized mice treated with C...

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Veröffentlicht in:Journal of allergy and clinical immunology 2007, Vol.119 (1), p.S3-S3
Hauptverfasser: Haapakoski, R, Fyhrquist-Vanni, N, Savinko, T, Wolff, H, Turjanmaa, K, Palosuo, T, Reunala, T, Lauerma, A, Alenius, H
Format: Artikel
Sprache:eng
Schlagworte:
Allergies
Allergy and Immunology
Asthma
Cytokines
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Zusammenfassung:Expression of regulatory cytokines TGF-β and IL-10 and, Foxp3, a specific marker for regulatory T cells, was significantly enhanced in the airways of CpG treated mice. [...]the levels of NRL-specific IgE were reduced and NRL-specific IgG2a levels were increased in NRL sensitized mice treated with CpG.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2006.11.029