Effects of Recombinant Human Hyaluronidase (rHuPH20) on Subcutaneous Administration of 10% and 20% IgG in Yucatan Mini Pigs

Effects of Recombinant Human Hyaluronidase (rHuPH20) on Subcutaneous Administration of 10% and 20% IgG in Yucatan Mini Pigs

RATIONALE: rHuPH20 is a novel drug delivery enzyme that locally degrades hyaluronan and transiently increases bulk fluid flow, thereby facilitating improved subcutaneous (SC) absorption profiles of co-administered agents.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.AB139-AB139
Hauptverfasser: Bee, W.H, Nekoroski, T, Zhang, L, Kang, D, Teschner, W, Schwarz, H.P, Muchitsch, E.M
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Histopathology
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Zusammenfassung:RATIONALE: rHuPH20 is a novel drug delivery enzyme that locally degrades hyaluronan and transiently increases bulk fluid flow, thereby facilitating improved subcutaneous (SC) absorption profiles of co-administered agents.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.12.546