Alternaria Activates cSrc -Cathepsin K Danger Pathway-dependent Release Of Pro-inflammatory Cytokines From Airway Epithelial Cells

Alternaria extract induces necrosis of epithelial cells and release of HMGB1 and IL-18 by activating a novel cSrc-cathepsin K signaling pathway. Because IL-18 can boost allergic sensitization and allergic airway inflammation, we suggest that this "danger signaling pathway" mediates the pro...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.AB123-AB123
Hauptverfasser:	Murai, H, Qi, H, Vaidya, S, Kurosky, A, Boldogh, I, Sur, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Asthma Cytokines Phosphorylation
Online-Zugang:	Volltext
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