Alternaria Activates cSrc -Cathepsin K Danger Pathway-dependent Release Of Pro-inflammatory Cytokines From Airway Epithelial Cells

Alternaria Activates cSrc -Cathepsin K Danger Pathway-dependent Release Of Pro-inflammatory Cytokines From Airway Epithelial Cells

Alternaria extract induces necrosis of epithelial cells and release of HMGB1 and IL-18 by activating a novel cSrc-cathepsin K signaling pathway. Because IL-18 can boost allergic sensitization and allergic airway inflammation, we suggest that this "danger signaling pathway" mediates the pro...

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Veröffentlicht in:Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.AB123-AB123
Hauptverfasser: Murai, H, Qi, H, Vaidya, S, Kurosky, A, Boldogh, I, Sur, S
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Asthma
Cytokines
Phosphorylation
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Zusammenfassung:Alternaria extract induces necrosis of epithelial cells and release of HMGB1 and IL-18 by activating a novel cSrc-cathepsin K signaling pathway. Because IL-18 can boost allergic sensitization and allergic airway inflammation, we suggest that this "danger signaling pathway" mediates the proinflamatory and proallergic effects of Alternaria in asthma and allergic diseases.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.12.487