Modulation of chemokine receptor expression on CLA+ T cells in atopic dermatitis

Differential expression of chemokine receptors on T cells from healthy individuals and those suffering with disease may help direct these T cells into different immune compartments. We systematically analyzed levels of expression of several CC and CXC chemokine receptors on CLA+ T cells from 27 atopic dermatitis (AD) and 22 healthy subjects. PBMCs were stained direct ex vivo, using antibodies against specific chemokine receptors (CCR1, 2, 3, 4, 5, 6, 7, and 9; CXCR1, 2, 3, 4, 5, 6), CLA, CD3, CD4 and CD45RO. The percentage of CLA+ T cells expressing receptors CCR5, CCR6, CCR7 and CXCR3 were significantly lower in AD subjects compared to healthy controls ( p