Anti-C1q-autoantibodies in SLE patients

Patients having autoimmune chronic diseases may develop anti-C1q- autoantibodies. Anti-C1q-autoantibodies were determined in sera from 42 SLE-patients treated at the Belarus Rheumatology Center. All diagnoses were confirmed according to American Rheumatology Association criteria. The majority of patients were female (95.2%). Clinical characteristics of patients: 4 (9%) had mild disease, 25 (60%) – moderate disease, and 13 (31%) – severe disease. The control group included 10 healthy adults. The concentration of anti-C1q- autoantibodies was determined by an ELISA method. The level of anti-C1q- autoantibodies in SLE patients (118.16 ± 24.88 U/ml) was significantly greater (p