Omenn Syndrome is Associated with Mutations in DNA Ligase IV

Omenn Syndrome is Associated with Mutations in DNA Ligase IV

Evaluation of the immune system revealed markedly elevated eosinophils, low CD3 + T cells, markedly reduced T cell response to mitogen stimulation and markedly reduced T cell receptor excision circles (TREC).

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Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology 2009-02, Vol.123 (2), p.S14-S14
Hauptverfasser: Kim, V.H.D, Grunebaum, E, Bates, A, Roifman, C.M
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Bone marrow
Deoxyribonucleic acid
DNA
Immune system
Lymphocytes
T cell receptors
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Zusammenfassung:Evaluation of the immune system revealed markedly elevated eosinophils, low CD3 + T cells, markedly reduced T cell response to mitogen stimulation and markedly reduced T cell receptor excision circles (TREC).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2008.12.064