Development of Multivalent Vaccine for Type 1 Diabetes Mellitus (T1DM) in NOD Mice

Development of Multivalent Vaccine for Type 1 Diabetes Mellitus (T1DM) in NOD Mice

The vaccination induced shifting of T cell response to Th2 type response, suppression of inflammatory cytokines IFN-γ and TNF-α, enhanced synthesis of regulatory cytokine IL-10, and induction of regulatory cell as proved by adoptive transfer and anti-insulin, anti-IA2 and anti-islet antibodies....

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Veröffentlicht in:Journal of allergy and clinical immunology 2009-02, Vol.123 (2), p.S15-S15
1. Verfasser: Lin, M.S
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Diabetes
Lymphocytes
T cell receptors
Vaccines
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Beschreibung
Zusammenfassung:The vaccination induced shifting of T cell response to Th2 type response, suppression of inflammatory cytokines IFN-γ and TNF-α, enhanced synthesis of regulatory cytokine IL-10, and induction of regulatory cell as proved by adoptive transfer and anti-insulin, anti-IA2 and anti-islet antibodies.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2008.12.071