Adoptive Immunotherapy of Experimental Autoimmune Hearing Loss via T Cell Delivery of the IL-12 p40 Subunit

Adoptive Immunotherapy of Experimental Autoimmune Hearing Loss via T Cell Delivery of the IL-12 p40 Subunit

[...]systemic administration of anti-inflammatory cytokines has nonspecific toxicity and often results in systemic immune suppression limit the usefulness of systemic cytokine delivery as a potential therapy.Therefore, we used the site-specific trafficking properties of autoantigen-reactive CD4 + T...

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Veröffentlicht in:Journal of allergy and clinical immunology 2009-02, Vol.123 (2), p.S208-S208
Hauptverfasser: Zhou, B, Kermany, M.H, Zhou, Y, Cai, C, Cai, Q, Tarner, I.H, Fathman, C.G, Kim, P, Kim, J, Liu, W, Yoo, T
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Autoimmune diseases
Hearing loss
Lymphocytes
Rodents
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Zusammenfassung:[...]systemic administration of anti-inflammatory cytokines has nonspecific toxicity and often results in systemic immune suppression limit the usefulness of systemic cytokine delivery as a potential therapy.Therefore, we used the site-specific trafficking properties of autoantigen-reactive CD4 + T cells to develop an adoptive immunotherapy protocol that provided local delivery of a Th1 cytokine antagonist, the p40 subunit of IL-12.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2008.12.793